Research
Senescent cells are old or damaged cells. They release chemicals that can cause inflammation and damage nearby healthy cells. Senescent cells are present throughout our body, including in the skin, brain, muscles, and heart. Stressors, including poor diet, lack of sleep, stress, and sun can trigger cells to become senescent. But the main cause is aging. As they build up in our body, senescent cells can induce inflammation and accelerate age-related illnesses.
Cellular Senescence: Aged Damaged Cells Amplifying Their Damage
The Birth of Inflammaging: Studying Life-Long Aging
How do we get rid of senescent cells?
Senescent cells are normally cleared quickly by the immune system, immune cells recognize senescent cells and remove them to keep tissues healthy.
How It Works:
Senescent cells release chemical signals (cytokines) that alert the immune system.
NK cells and macrophages detect them and trigger their destruction.
T cells also help clear senescent cells by attacking them directly or enhancing immune response.
Senescent cells accumulate as we age, exponentially faster after 60
Immune Response to Senescent Cells to Combat Aging
Cellular Senescence & The Adaptive Immune System: Understanding the Interplay
Why do Senescent Cells accumulate with age?
The immune system’s surveillance (ability to identify and eliminate senescent cells) diminishes, resulting in the buildup of senescent cells.
This leads to:
Chronic inflammation because senescent cells keep releasing harmful signals
Tissue damage and age-related diseases
Arthritis
Heart disease
Neurodegeneration
The Connection: Impaired Immune Function, Senescent Cells and Aging
Inflammation & Aging: Signaling Pathways & Intervention Therapies
Activate Immune Cell Communication
Immune cells recognize and destroy senescent cells. Certain compounds (polyphenols) have been shown to boost immune cell communication.
Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences
Restore Function
Immune cells recognize and destroy senescent cells. Some natural compounds, (beta-glucans and fucoidan) have been shown to boost immune cell activity.
Fucoidans Stimulate Immune Reaction and Suppress Cancer Growth
Immunostimulatory Effect of Laminarin on RAW 264.7 Mouse Macrophages
Repair Damage
Stem cells are responsible for repairing and replacing damaged tissues. As we age, our stem cells become less active, leading to slower healing. Active stem cells can replace senescent cells. This can slow down age-related diseases like arthritis, cardiovascular disease, and neurodegeneration, and improve skin elasticity, muscle recovery, and organ function, helping maintain a more youthful appearance and physical vitality.
Fucoidan Boosts Stem Cell Function and Blood Flow in Kidney Disease-Related Limb Damage
Fucoidan Supports Bone Cell Development Through Key Signaling Pathways
Natural Antiaging Support Youthfullness and Vitality
Activate
Get immune cells communicating with each other
Restore
Get immune cells moving to clear out senescent cells and invaders (viruses) to reduce disease risk and inflammation
Repair
Get stem cells moving to repair damage and create new cells
Polyphenols
Reduce inflammation and support immune signaling.
Fucoidan
Boosts immune cell function and immune surveillance
Beta-Glucans
Enhance macrophage activity to remove/destroy senescent cells
Stem Cells
Repair or replace damaged cells
20 participant placebo controlled, cross-over, randomized, double-blind study with blood draws
NIS Labs, founded by Gitte Jensen, PhD, is the North American leader in clinical studies for the natural products industry.
Testing has shown consuming PolySeaTM leads to a rapid increase in antioxidant protection, alertness of the immune system and activation of stem cells.
Within 1-2 hours!
60 healthy women aged 30-50, experiencing early to moderate signs of aging. Key anti-aging outcomes: wrinkles, fine lines, dark spots, skin hydration, texture, firmness, and elasticity. Results were evaluated through dermatological assessments, instrumental measurements, and participant self-assessments. The study design was monocentric, double blinded, full face, randomised, efficacy and safety. The product was applied twice daily. The test sites were face and forearm for 9 weeks including one week of wash out period
At week 4, more than 90% of study participants agreed PolySea™ made their skin: feel firmer, feel hydrated, feel moisturized, feel smooth and even, feel lifted, feel healthier, softened lines around their eyes, look brighter
By week 8, all the participants reported that the test product effectively faded their dark spots.